“Laughter is the best medicine” is one of those sayings that’s easy to dismiss as a greetings-card cliché — but there’s a genuine, measurable body of research behind it. Laughter triggers real physiological changes, from stress hormone reduction to mood-lifting neurochemicals, and a small but growing number of controlled studies have tried to quantify exactly how much it helps. Here’s what the evidence shows.
The clearest evidence: laughter lowers cortisol
The most rigorous evidence comes from a systematic review and meta-analysis published via the National Institutes of Health, which pooled data from 8 studies and 315 participants to look specifically at spontaneous laughter and cortisol, the body’s primary stress hormone. The results were striking: laughter interventions produced a 31.9% average reduction in cortisol compared with control activities. Even a single laughter session produced a 36.7% reduction, and when the analysis was restricted to only the four highest-quality randomised controlled trials, the effect held at a 37.2% reduction. Salivary cortisol measurements showed an even larger effect (43.9% reduction) than blood serum measurements (22.0%).
The studies included in this analysis used a range of laughter triggers — comedy videos, structured laughter therapy sessions, and self-administered laughter exercises — suggesting the effect isn’t dependent on one specific method. That said, the review’s authors were upfront about real limitations: small sample sizes, inconsistent timing of cortisol sampling, an inability to blind participants to whether they were laughing, and an overall evidence quality rated moderate-to-low under the GRADE framework used to assess medical research. In plain terms: the effect looks real and is consistent across multiple studies, but the research base is still relatively small.
Mood, memory and the brain
Beyond cortisol, laughter is associated with the release of dopamine and serotonin, neurotransmitters linked to calm, positive mood. According to Stanford Lifestyle Medicine, laughter’s cortisol-lowering effect may also help protect memory, since chronically elevated cortisol is known to damage the hippocampus — the brain region central to learning and memory formation. Research specifically in adults over 65 found that laughter improved short-term memory, and notably, simply anticipating something funny was enough to lower cortisol by nearly half in that age group, suggesting the anticipation of joy carries some of the same benefit as the laughter itself.
A meaningful but not miraculous effect
It’s worth being precise about what this evidence does and doesn’t show. Laughter is not a treatment for clinical depression or anxiety disorders, and none of the studies above suggest it should replace therapy or medication when those are clinically indicated. What the research does support is that laughter functions as a genuine, physiologically measurable stress-reduction tool — comparable in effect size to other short-term relaxation techniques like a brief walk or a few minutes of deep breathing, rather than a cure-all. Its main advantages are that it’s free, requires no equipment or training, and can be worked into daily life more easily than most relaxation practices.
How to build more laughter into daily life
You don’t need to wait for spontaneous humour to show up. Deliberately watching a comedy clip, calling a friend who makes you laugh, or setting aside time for a genuinely funny show are all supported by the research above, since several of the studies used exactly these kinds of triggers. Some structured laughter therapy programmes use exercises where participants laugh without a specific joke prompting it — research on this “self-administered” laughter found stress-reduction benefits too, and the contagious nature of laughter (partly explained by mirror neurons, the brain cells that fire both when we act and when we watch someone else act) means it tends to spread and feel genuine even when it starts deliberately.
Building small, regular moments of humour into a day — a funny podcast on a commute, a few minutes of a favourite comedian, sharing a joke with a colleague — is a low-effort way to apply this research practically, rather than treating laughter as something that only happens by chance.
Laughing with others versus laughing alone
Most of the research above measured laughter triggered by an external source, such as a comedy video, or laughter shared in a group setting during structured laughter therapy sessions, and it’s worth noting that social laughter carries an additional benefit layer beyond the cortisol effect. Laughing with another person adds a genuine social-bonding element on top of the physiological stress reduction, tied to the same oxytocin and connection-related mechanisms that make shared positive experiences generally more emotionally significant than solitary ones. That’s not a reason to dismiss the benefit of laughing at something funny alone, but it’s a reason to specifically seek out shared laughter with friends or family where possible, rather than treating it purely as a private stress-management technique.
The bottom line
The evidence for laughter as a stress-reduction tool is more solid than the cliché suggests: multiple studies, including randomised trials, show a consistent and meaningful drop in cortisol after laughter, alongside mood and memory benefits linked to the same mechanism. The effect is moderate rather than dramatic, and the research base, while consistent, is still relatively small. But as free, accessible stress-relief tools go, deliberately building more laughter into your day is about as low-risk and evidence-backed as it gets.
Sources
- “Laughter as medicine: A systematic review and meta-analysis of interventional studies evaluating the impact of spontaneous laughter on cortisol levels,” National Institutes of Health / PMC
- Stanford Lifestyle Medicine, “Brain Health Benefits of Laughter”
